BIOL. 341 - GENETICS
COURSE SUPPLEMENTS
FROM COLD SPRING HARBOR LABORATORY (CSHL)
 AND UNIVERSITY OF WASHINGTON (UW)
SPRING SEMESTER 2004 

Listed below are the major topics for the lecture and laboratory components of Biol. 341 - Genetics.  Below each topic are links to supplementary material provided by the Dolan DNA Learning Center at Cold Spring Harbor Laboratory (CSHL) and the Department of Pathology, University of Washington (UW).  The CSHL supplements require Macromedia Flash Player and RealPlayer Basic.  Free versions of these Players are available.

LECTURE TOPICS:

1.   Introduction:

CSHL Concept 1.  Children resemble their parents

CSHL Concept 2.  Genes come in pairs

CSHL Concept 3.  Genes don't blend

CSHL Concept 4.  Some genes are dominant

CSHL Concept 6.  Genes are real things

2.   Nature of the Hereditary Material:

CSHL Concept 15.  DNA and proteins are key molecules of the cell nucleus

CSHL Concept 17.  A gene is made of DNA

CSHL Concept 19.  The DNA molecule is shaped like a twisted ladder

CSHL Concept 20.  A half DNA ladder is a template for copying the whole

CSHL Concept 23.  A gene is a discrete sequence of DNA nucleotides

3.   Function of the Hereditary Material:

CSHL Concept 16.  One gene makes one protein

CSHL Concept 21.  RNA is an intermediary between DNA and protein

CSHL Concept 22.  DNA words are three letters long

CSHL Concept 31.  Some DNA does not encode protein

4.   Gene Mutation:

CSHL Concept 27.  Mutations are changes in genetic information

CSHL - Marfan Syndrome

CSHL - Fragile X Syndrome 

CSHL - Huntington Disease

CSHL Concept 28.  Some types of mutations are automatically repaired

CSHL Concept 32.  Some DNA can jump

5.   Fundamentals of Classical Genetics:

Review:  CSHL Concept 4.  Some genes are dominant

CSHL Concept 5.  Genetic inheritance follows rules

CSHL Concept 10.  Chromosomes carry genes

CSHL Concept 13.  Mendelian laws apply to human beings 

CSHL - Cystic Fibrosis

CSHL - Hemophilia

CSHL - Duchenne / Becker Muscular Dystrophy

CSHL - Phenylketonuria 

CSHL - Sickle Cell Disease

6.   Quantitative Genetics:

7.   Population Genetics:

CSHL Concept 12.  Evolution begins with the inheritance of gene variations

8.   Genetics of Bacteria and Viruses:

CSHL Concept 18.  Bacteria and viruses have DNA too

CSHL Concept 25.  Some viruses store genetic information in RNA

9. Genetic Manipulation:

CSHL Concept 34.  Genes can be moved between species

CSHL Concept 39.  A genome is an entire set of genes

LABORATORY TOPICS:

Lab 1:   Introduction to Drosophila I:

Lab 2:   Introduction to Drosophila II:

Lab 3:   Chromosomes of Eukaryotes:

Review:  CSHL Concept 6.  Genes are real things

CSHL Concept 29.  DNA is packaged in a chromosome

Lab 4:   Mitosis:

CSHL Concept 7.  All cells arise from pre-existing cells

Lab 5:   Meiosis:

CSHL Concept 8.  Sex cells have one set of chromosomes; body cells have two

Lab 6:   Sex Chromosomes and Sex Determination:

CSHL Concept 9.  Specialized chromosomes determine gender

Lab 7:   Introduction to Statistics:

Lab 8:   Linkage and Crossing Over:

Review:  CSHL Concept 32.  Some DNA can jump

Lab 9:   Recombination and Gene Mapping:

CSHL Concept 11.  Genes get shuffled when chromosomes exchange pieces

Lab 10: Changes in Chromosome Structure:

Review:  CSHL Concept 31.  Some DNA does not encode protein

UW - Cytogenetics Gallery

Lab 11: Changes in Chromosome Number:

UW - Cytogenetics Gallery 

 Lab 12: Gene Regulation:

CSHL Concept 33.  Genes can be turned on and off

CSHL Concept 35.  DNA responds to signals from outside the cell 

CSHL Concept 36.  Different genes are active in different cells

CSHL Concept 37.  Master genes control basic body plans

 

CONTACT PERSON:  Robert Weibust - weibust@mnstate.edu

LAST UPDATE:  5/17/04

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